Studies from Ewha Woman's University have provided new data on life sciences in children

In this recently published study, investigators in Seoul, South rings conducted a study "To determine if fentanyl-induced cough was dose-dependent in children and whether it could affect tracheal intubation. Prospective, randomized, double-blinded study."

"Operating room of a university-affiliated hospital. 160 ASA physical status I pediatric patients, aged two to 14 years, scheduled for elective surgery during general anesthesia and requiring orotracheal intubation. Patients were divided into two groups. Group 1 patients were given fentanyl at a dosage of one microg/kg; Group 2 patients received two microg/kg of fentanyl. Induction of anesthesia was conducted immediately following cough cessation or one minute after the end of injection with propofol 2.5 mg/kg. At loss of eyelash reflex, rocuronium 0.6 mg/kg was given intravenously (IV). Two minutes later, tracheal intubation was started. Onset and degree of cough and intubating conditions were observed and recorded. bracelets statistically significant differences in frequency of coughing or in intubating conditions between the two groups were noted. Cough severity in Group 1 was statistically lower than that of Group 2 (p <0.05). Onset of cough in Group 2 (12.2 +-3.4 sec) was statistically shorter than in Group 1 (16.9 +-7.6 sec, p<0.05)," wrote J.I. Han and colleagues, Ewha Woman's University.

The researchers concluded: "Fentanyl at doses of one and two microg/kg may induce coughing in pediatric patients."

Han and colleagues published their study in the Journal of Clinical Anesthesia (The frequency of fentanyl-induced cough in children and its effects on tracheal intubation. Journal of Clinical Anesthesia, 2010;22(1):3-6).

For additional information, contact J.I. Han, School of Medicine, Dept. of Anesthesiology and Pain Medicine, Ewha Womans University, Seoul 158-710, South Korea.

Keywords: City:Seoul, Country:South Korea, Life Sciences, tiffany, Pain Medicine, Anesthesia, Medical Device, Critical Care Medicine, Fentanyl Citrate, Pharmaceuticals, Drugs, Therapy, Treatment, Clinical Anesthesia, Surgery.